Combined oral toxicity of azaspiracid-1 and yessotoxin in female NMRI mice
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چکیده
منابع مشابه
Combined oral toxicity of azaspiracid-1 and yessotoxin in female NMRI mice.
For many years, the presence of yessotoxins (YTXs) in shellfish has contributed to the outcome of the traditional mouse bioassay and has on many occasions caused closure of shellfisheries. Since YTXs do not appear to cause diarrhoea in man and exert low oral toxicity in animal experiments, it has been suggested that they should be removed from regulation. Before doing so, it is important to det...
متن کاملMice. Four-week-old inbred male and female NMRI mice
Source of Compounds. DMBA was supplied by EGA-Chemie, Steinheim, Germany, and l,2,3,4-dibenzanthracene (1,2,3,4DBA) by Nutritional Biochemicals Co., Cleveland, Ohio. The labeled compounds thymidine-3H and uridine-3H were purchased from the Radiochemical Centre, Amersham, En gland. The cocarcinogenic compound Al was prepared by Dr. H. Bresch, Heidelberg, Germany. Mice. Four-week-old inbred male ...
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Background: Ferula species have shown wide range of pharmacological properties but there is no study on oral safety profile of Ferula persica due to standard toxicology guidelines. Objective: This study aimed to evaluate the acute and subchronic oral toxicity of the alcoholic extract of the aerial parts of Ferula persica to provide its safe dose for long term oral administrations as a possible...
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چکیده ندارد.
15 صفحه اولEffects of Memantine, an NMDA Antagonist, on Metabolic Syndromes in Female NMRI Mice
Introduction: The brain glutamate neurotransmitter system and its NMDA receptors in the nucleus accumbens play an important role in the incidence of the phenomena of sensitivity and addiction. The present study examined the inhibitory effect of glutamate NMDA receptors in the nucleus accumbens in response to chronic stress. Methods: After the unilateral and bilateral cannula placement in the ...
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ژورنال
عنوان ژورنال: Toxicon
سال: 2011
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2011.03.014